Researchers Identify 4 Predictors of Transition to Chronic Opioid Use Based on Readily Available Opioid Regimen and Patient Factors

Press Releases - Clinical

Cranbury, NJ, February 27, 2018--In a new study published in February 2018 in American Health & Drug Benefits, researchers have identified opioid prescription characteristics that may increase the patient’s risk for becoming a chronic user of opioid therapy. View the article here.

In light of the current opioid epidemic in the United States, it is important to understand the use of chronic opioid therapy among working-age adults, who may have unique and negative consequences, such as missed work days, loss of employment, and decreased productivity, in addition to complications associated with opioid use (eg, high economic burden from increased emergency department, inpatient, and other health services utilization).

This is the first study to identify incident chronic opioid use among working-age adults who initiate opioid therapy. This is an important group, because of the potential impact on their productivity and their increased likelihood to use opioid therapy when they experience pain.

The 4 leading predictors identified that increase the risk for transitioning to chronic opioid use by at least 4 times are:

  1. The drug’s duration of action
  2. Type of parent opioid compounds
  3. The patient’s drug use disorder
  4. Pain conditions

In this study, adults who were prescribed long-acting opioids as opposed to immediate-release opioids had the highest likelihood of transitioning to chronic opioid therapy use.

In addition, the rates of patients who became chronic opioid users were higher in Ohio, West Virginia, Kentucky, Mississippi, and Nevada than in other states.

“These findings suggest that the likelihood of an individual’s transitioning to chronic opioid use can be predicted by information that is readily available to providers in a clinical setting, such as the initial opioid regimen characteristics, the patient’s history of drug use disorder, and the medical conditions associated with pain,” said Douglas Thornton, PharmD, PhD, lead investigator and Assistant Professor, College of Pharmacy, Department of Pharmaceutical Health Outcomes and Policy, University of Houston, TX.

“The very timely article by Thornton and colleagues can play a role in addressing our current epidemic of opioid abuse,” said Albert Tzeel, MD, MHSA, CPE, FAAPL, Regional Medical Director, Senior Products, North Florida, Humana, Tampa, in his accompanying commentary. “It is well known that prescribing opioid medications, especially those with protracted durations of action or over a longer time frame, increases the risk for an individual using these medications to become addicted to and/or physiologically dependent on them. It is in this realm that the article by Thornton and colleagues becomes extremely valuable,” Dr. Tzeel added.

The investigators from the University of Houston (D. Thornton), West Virginia University (N. Dwibedi, V. Scott, C. Ponte, and U. Sambamoorthi), University of California San Diego (D. Ziedonis), and Northwestern University (N. Sambamoorthi), note that “the importance of these factors could change, and the overall prediction improved, if and when other types of information are added to the data. Further intervention research, working with patients, prescribers, and healthcare payers, is needed to optimize opioid use and prevent unnecessary adverse events.”

About American Health & Drug Benefits
American Health & Drug Benefits®: The Peer-Reviewed Journal for Real-World Evidence in Benefit Design™ is a peer-reviewed journal founded on the concept that the economic value of a therapy is of equal importance to its clinical outcomes, and this combination serves as the basis for insurance coverage decisions and benefit designs. The journal offers a forum for stakeholder integration and collaboration toward the promotion of value-based healthcare by integrating the clinical, business, and policy issues related to drug therapy, and is published by Engage Healthcare Communications, LLC, an affiliate of The Lynx Group.

About The Lynx Group

The Lynx Group is a rapidly growing global strategic alliance of medical communications and education companies. Through its unique business model, The Lynx Group strives to provide pivotal and contemporary information and education for all stakeholders in healthcare.

 

 

Related Items
Patient Preferences and Therapeutic Satisfaction with Topical Agents for Rosacea: A Survey-Based Study
Todd Williamson, PhD, MSc, Wendy Y. Cheng, MPhil, MPH, Nora McCormick, MSc, Francis Vekeman, MA
April 2018 Vol 11, No 2 published on April 13, 2018 in Clinical, Original Research
Predictors of Transitioning to Incident Chronic Opioid Therapy Among Working-Age Adults in the United States
J. Douglas Thornton, PharmD, PhD, Nilanjana Dwibedi, PhD, Virginia Scott, PhD, Charles D. Ponte, PharmD, Douglas Ziedonis, MD, Nethra Sambamoorthi, PhD, Usha Sambamoorthi, PhD
February 2018 Vol 11, No 1 published on February 26, 2018 in Clinical
Newly Diagnosed Hepatitis C in the US Commercially Insured Population Before and After the 2012 Implementation of Expanded Screening Guidelines
Gabriela Dieguez, FSA, MAAA, Christine Ferro, Maushumi Mavinkurve, MPH, Yuri Sanchez Gonzalez, PhD, Bruce Pyenson, FSA, MAAA
February 2018 Vol 11, No 1 published on February 26, 2018 in Clinical
Major Cardiovascular Events in Patients with Gout and Associated Cardiovascular Disease or Heart Failure and Chronic Kidney Disease Initiating a Xanthine Oxidase Inhibitor
JoAnne Foody, MD, Robin S. Turpin, PhD, Beni A. Tidwell, BS, Debra Lawrence, PhD, Kathy L. Schulman, MS
November 2017 Vol 10, No 8 published on November 21, 2017 in Clinical, Original Research
Medication Adherence, Treatment Patterns, and Dose Reduction in Patients with Metastatic Castration-Resistant Prostate Cancer Receiving Abiraterone Acetate or Enzalutamide
Ajay S. Behl, PhD, Lorie A. Ellis, PhD, Dominic Pilon, MA, Yongling Xiao, PhD
September 2017 Vol 10, No 6 published on September 20, 2017 in Clinical, Original Research
Last modified: February 26, 2018
  •  Association for Value-Based Cancer Care
  • Value-Based Cancer Care
  • Value-Based Care in Rheumatology
  • Oncology Practice Management
  • Rheumatology Practice Management
  • Urology Practice Management
  • Inside Patient Care: Pharmacy & Clinic
  • Lynx CME