Value-Based Care in Cardiometabolic Health May 2012, Vol 1, No 1

Chicago, IL—A fully human monoclonal antibody lowered low-density lipoprotein cholesterol (LDL-C) levels an additional 40%, to 72% in hypercholesterolemic patients already being treated with atorvastatin (Lipitor).

Chicago, IL—A meta-regression analysis found that adding a therapy that raises high-density lipoprotein cholesterol (HDL-C) to a statin is unlikely to produce a substantial clinical benefit, said Brian A. Ference, MD, MPhil, MSc, FACC, Associate Chief of Translational Research and Clinical Epidemiology, Director of the Cardio vascular Genomic Research Center and Assistant Professor of Medicine at Wayne State University School of Medicine, Detroit, MI, at the 2012 American College of Cardiology meeting.

Chicago, IL—A retrospective analysis of high-risk patients in a managed care setting shows that those who were newly prescribed statin therapy were usually started at low-to-moderate doses, and approximately 50% of them had discontinued therapy within 12 months, reported Terry A. Jacobson, MD, Professor of Medicine and Director of the Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA.

Chicago, IL—“Difficult” atrial fibrillation (AF), for which standard ratecontrol therapy or standard rhythmcontrol therapy has not been effective, or AF in the setting of sinus node or other conduction disease, has been shown to sometimes benefit from nonstandard or combination-drug treatment, according to James A. Reiffel, MD, Professor of Clinical Medicine, Columbia University Medical Center, New York City.

Chicago, IL—Cardiac resynchronization therapy (CRT) in the setting of atrial fibrillation (AF) and heart failure (HF) has clear challenges, and the evidence is mixed about its benefit.

Chicago, IL—In patients with atrial fibrillation (AF) who underwent catheter ablation, the new anticoagulant dabigatran (Pradaxa), an oral direct thrombin inhibitor, was found to effectively prevent thromboembolic events in a small prospective study presented by Charlotte Eitel, MD, Department of Electrophysiology, Heart Center Leipzig, Germany, at the 2012 American College of Cardiology meeting. Patients with AF are known to be at increased risk for thromboembolic events.

Chicago, IL—A blood test for galectin-3, a unique protein that binds to carbohydrates known as “beta-galactosides,” appears to be a reliable predictor of incident heart failure (HF) and of the response to treatment for HF, reported Jennifer E. Ho, MD, a practicing cardiologist in San Francisco, CA, using data from the National Heart, Lung, and Blood Institute’s Framingham Heart Study, at the 2012 American College of Cardiology meeting.

Chicago, IL—A phase 2 study of autologous bone marrow–cell therapy in patients with chronic ischemic heart disease and left-ventricular dysfunction showed no significant differences for the primary end points, but there were hints of benefit from the prespecified exploratory analyses that point to refinements for future studies that will build on these results, according to the study’s lead investigator, Emerson C. Perin, MD, PhD, Director of Clinical Research for Cardiovascular Medicine, Texas Heart Institute, Houston.

Chicago, IL—Remote disease management is effective and more efficient for patients, their caregivers, and for physicians. Although there are few data on its cost-effectiveness, the value for the patient and for guiding treatment is high, by reducing hospitalizations and improving management of arrhythmias. The value and benefits of remote disease management and its effect on improving clinical outcomes were the focus of a clinical session at the 2012 American College of Cardiology (ACC) meeting.

Remote Monitoring for Arrhythmias

Chicago, IL—In patients at low to intermediate risk of coronary artery disease (CAD) presenting with chest pain, a rule-out strategy using primary coronary computed tomographic angiography (CTA) versus traditional care was found to be safe and effective to determine patients who could be discharged directly from the emergency department, according to lead investigator Harold I. Litt, MD, PhD, Chief of Cardiovascular Imaging, Department of Radiology, the Perelman School of Medicine, University of Pennsylvania, Philadelphia.

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