Multiple Myeloma

The oral anti­myeloma proteasome inhibitor oprozomib, given as a single agent in a dose-escalation study, “showed promising antitumor activity,” which included responses even in patients with carfilzomib-refractory multiple myeloma, according to Ravi Vij, MD, of Washington University in St Louis, MO.
Data from a phase 1/2 clinical trial support further evaluation of the investigational oral proteasome inhibitor ixazomib in combination with lenalidomide and dexamethasone for the treatment of patients with newly diagnosed multiple myeloma.
In the treatment of patients newly diagnosed with multiple myeloma, medical, nondrug costs, particularly outpatient costs, account for approximately 75% of the total expenditures for the first 2 years after diagnosis, according to a new analysis of a large US claims database presented at ASH 2014.
The results of studies presented at ASCO 2014 highlight 2 novel drug classes that showed strong activity in multiple myeloma (MM), representing potential advances in relapsed or refractory disease.
New Orleans, LA—The value of the continued use of lenalidomide (Rev­limid) in patients with newly diagnosed multiple myeloma (MM) was highlighted in a phase 3 clinical trial that was featured in a plenary session during ASH 2013.
New Orleans, LA—The FIRST (Frontline Investigation of Rev­limid plus Dexamethasone versus Standard Thalidomide) trial in transplant-ineligible patients demonstrated the benefit of continuous lenalidomide (Revlimid).
New Orleans, LA—Emerging agents for multiple myeloma (MM) are promising as future treatment options. The arsenal now includes many new classes of agents beyond the standard immunomodulatory drugs (IMiDs) and proteasome inhibitors. Here is a look at the key studies presented at ASH 2013.

Atlanta, GA—Support for the oral immunomodulatory agent pomalidomide for the treatment of multiple myeloma took a giant step forward when new data from the phase 3 MM-003 trial showed a survival advantage in patients with advanced disease.

The data were reported at the 2012 American Society of Hematology meeting by Meletios Dimopoulos, MD, Professor and Chairman of the Department of Clinical Therapeutics at Alexandra Hospital in Athens, Greece.

Median overall survival (OS) for patients with multiple myeloma has improved substantially in the past 10 years, thanks to the approval of a number of new drugs. For patients who can undergo transplants, survival exceeds 80% at 5 years. But although many patients can live 7 to 10 years after diagnosis, outcomes can be highly variable, according to S. Vincent Rajkumar, MD, Professor of Medicine at the Mayo Clinic in Rochester, MN.

 Patients with newly diagnosed myeloma who received a 4-drug regimen for induction, followed by a 2-drug maintenance approach, demonstrated a significant survival benefit and a significant delay in developing symptomatic disease, according to a study from the Italian Gruppo Italiano Malattie Ematologiche dell’Adulto (GIMEMA) network presented at ASH 2012.

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