Patricia Sacco, MPH, RPh, Gorana Capkun-Niggli, PhD, Xin Zhang, MS, Rosemary Jose, PhD, Michael F. Murphy, MD, PhD
Fragile X syndrome (FXS) is the most common form of inherited intellectual disability, with cognitive and behavioral impairments of varying degrees that are associated with distinct physical features.1 This neurodevelopmental disorder is caused by the silencing of a single X-linked gene, the fragile X mental retardation 1 gene, and hence manifests primarily in males.
Rarity, Disease Heterogeneity, and a Pathway for Estimating Economic Burden
Budget Impact Model: Epigenetic Assay Can Help Avoid Unnecessary Repeated Prostate Biopsies and Reduce Healthcare Spending
Wade Aubry, MD, Robert Lieberthal, PhD, Arnold Willis, MD, Grant Bagley, MD, Simon M. Willis III, MS, Andrew Layton, BA
Prostate cancer is the most frequently detected cancer in men, and 1 of 6 men will be diagnosed with prostate cancer during their lifetime based on Medicare enrollment data.1 In the United States, approximately 19 million men annually are screened by prostate-specific antigen (PSA) testing,2 resulting in approximately 4.7 million abnormal PSA test results (≥4.0 ng/mL)3 leading to approximately 1.3 million biopsy procedures.4 According to the National Cancer Institute, 241,740 men are diagnosed with prostate cancer annually, and 28,170 prostate
Molecular Epigenetic Tests Can Improve Clinical Outcomes While Reducing Healthcare Costs
The Opportunity for Health Plans to Improve Quality and Reduce Costs by Embracing Primary Care Medical Homes
The large and growing cost of healthcare, which amounted to 17.9% of the gross domestic product in 2011,1 will continue to be a burden for all payers in the US healthcare system, not only for states that are struggling to meet Medicaid costs and the federal government’s requirements, but also for private health plans that serve commercial, Medicare Advantage, and Medicaid beneficiaries.2,3 Costs will continue to grow as millions more people become newly insured because of the Patient Protection and Affordable Care Act (ACA).
Enhancing Health Outcomes and Quality of Care with the Medical Home Model in Primary Care
Current and Future Use of HEOR Data in Healthcare Decision-Making in the United States and in Emerging Markets
Anke-Peggy Holtorf, PhD, MBA, Diana Brixner, RPh, PhD, Brandon Bellows, PharmD, Abdulkadir Keskinaslan, MD, MBA, MPH, Joseph Dye, RPh, PhD, Gary Oderda, PharmD, MPH
With increasing access and utilization of healthcare, resources become more restricted, and prioritization in healthcare becomes unavoidable. Health economics and outcomes research (HEOR) is a discipline that is used to complement traditional clinical development information (ie, efficacy, safety, quality) to guide decision makers regarding patient access to specific drugs and services. HEOR has advanced considerably in methodology and in quantity over the past several decades.
Health Economics and Outcomes Research Data Key in Coverage Decisions of New Medications
Hematologic Complications, Healthcare Utilization, and Costs in Commercially Insured Patients with Myelodysplastic Syndrome Receiving Supportive Care
Annette Powers, PharmD, MBA, Claudio Faria, PharmD, MPH, Eunice Chang, PhD, Dasha Cherepanov, PhD, Jeffrey A. Bourret, PharmD
Myelodysplastic syndrome (MDS) encompasses a heterogeneous group of clonal disorders of hematopoiesis and is characterized by dysplastic morphology of marrow and blood cells, ineffective hematopoiesis, and peripheral blood cytopenias.1,2 Most patients with MDS experience progressive worsening of blood cytopenias, with an increasing need for transfusion.2 These patients also have an increasing number of potentially fatal infections and hemorrhagic complications.2 The more advanced and severe the MDS is, the greater the risk that the disease will progress to a
Reconsidering the Management of Younger Patients with Myelodysplastic Syndrome
Medical Care Costs and Hospitalization in Patients with Bipolar Disorder Treated with Atypical Antipsychotics
Joette Gdovin Bergeson, PhD, MPA, Iftekhar Kalsekar, PhD, Yonghua Jing, PhD, Min You, MS, Robert A. Forbes, PhD, Tony Hebden, PhD
Bipolar disorder is a chronic, recurring disorder associated with frequent episodes of mania and depression.
The Potential Value of Benefit Design and Medication Selection for a Total-Cost-of-Care Strategy in Bipolar Disease
The eighteenth-century essayist and satirist Jonathan Swift made the observation that “vision is the art of seeing things invisible.” So, too, is “the art of seeing things invisible” a key for the ongoing sustainability of health information exchange (HIE). HIEs have long been theorized to provide a number of tangible benefits.
Significant Potential for Health Information Exchange in Enhancing Quality of Care and Reducing Hospital Admissions in the United States
Curbing the Costly Trend: Exploring the Need for a Progressive Approach to the Management of Specialty Pharmaceuticals Under the Medical Benefit
Emerging Trends in Cancer Care: Health Plans’ and Pharmacy Benefit Managers’ Perspectives on Changing Care Models
Pompe disease is a rare condition, with a global incidence rate estimated to be between 1 in 40,000 (0.0025%) and 1 in 300,000 (0.0003%) live births.1 According to a study published in 1998, the annual incidence of Pompe disease in New York City was estimated to be approximately 1 in 40,000 births, and approximately 90 babies are assumed born with Pompe disease in the United States annually.2 A similar incidence rate was found in the Dutch population (1 in 40,000 births), a relatively lower rate was found among the Chinese (1 in 50,000 births; 0.0020%), and a higher ra
Beyond “Patient Amusement”: New Treatments and Genetic Disease
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Results 61 - 70 of 114
Results 61 - 70 of 114