Emerging Therapies

Judging by the high attendance at sessions where data on the anti–programmed death (PD)-1 antibodies were presented, oncologists can hardly wait to have these immunotherapies in the clinic. The key data from ASCO 2014 regarding stage III/IV melanoma are presented here.
Several presentations at ASCO 2014 focused on the use of the anti–programmed death (PD)-1 monoclonal antibodies in non–small-cell lung cancer (NSCLC) and in renal-cell carcinoma.
Chicago, IL—A series of 8 phase 3 clinical trials that compared albiglutide, an investigational glucagon-like peptide (GLP)-1 receptor agonist, with 5 currently used treatment scenarios showed the drug effectively lowered hemoglobin (Hb) A1c, the primary outcome of the studies, in patients with uncontrolled type 2 diabetes. Albiglutide is administered once weekly, via an easy-to-use injection pen.
San Francisco, CA—Medications that act on the glucagon-like peptide (GLP)-1 pathway may protect patients with type 2 diabetes from developing heart failure, according to a single- center retrospective study.
Chicago, IL—The new drug class of so­dium glucose cotransporter (SGLT)-2 inhibitors was the subject of several poster presentations at the 2013 American Diabetes Association annual meeting. In addition to lowering blood glucose levels in a series of phase 3 clinical trials, these agents show weight-loss benefits as well.

Chicago, IL—Previous trials of maintenance therapy for patients with ovarian cancer have failed to show improved survival. A study presented at ASCO 2013 is the first successful phase 3 trial in this setting, showing that the targeted therapy pazopanib (Votrient) extended progression-free survival (PFS) by a median of 5.6 months in women with ovarian cancer. Women who were enrolled in the trial were free of the disease after the initial treatment with surgery and chemotherapy.

Munich, Germany—A total of 16 novel classes of drugs are under development for the management of lipoprotein metabolism toward the prevention of cardiovascular disease (CVD), according to John J.P. Kastelein, MD, PhD, Academic Medical Center, University of Amsterdam, the Netherlands. Dr Kastelein reviewed several of these approaches at the 2012 European Society of Cardiology (ESC) Congress.

Boston, MA—No glucose-lowering regimen has been shown to reduce macrovascular complications, such as myocardial infarction (MI) or stroke, but glucagon-like peptide (GLP)-1 agonism appears to have favorable effects on many surrogate markers for cardiovascular disease (CVD), according to presenters at the 2012 Cardiometabolic Health Congress.

Los Angeles, CA—Reductions in dys­pnea and cardiovascular (CV) death, and improvement in the signs and symptoms of congestion and worsening heart failure (HF), in the RELAX-AHF study were attributed to serelaxin, a novel investigational agent for the treatment of acute HF, which was compared with placebo plus conventional therapy.

Munich, Germany—The first-in-class agent LCZ696, an angiotensin receptor neprilysin inhibitor, was associated with greater reductions of several measures that are associated with worse outcomes in patients who have heart failure with preserved ejection fraction (HFpEF) compared with the angiotensin receptor blocker (ARB) valsartan.

Page 4 of 6
Results 31 - 40 of 51
  •  Association for Value-Based Cancer Care
  • Value-Based Cancer Care
  • Value-Based Care in Rheumatology
  • Oncology Practice Management
  • Rheumatology Practice Management
  • Urology Practice Management
  • Inside Patient Care: Pharmacy & Clinic
  • Lynx CME