Emerging Therapies

A new biosimilar to trastuzumab (Herceptin) antibody, MYL-14010, showed efficacy and safety comparable to the reference drug (trastuzumab) as first-line treatment for patients with HER2-positive advanced breast cancer, according to results from the 24-week, randomized phase 3 HERITAGE study presented at ASCO 2016.

The first-in-class antibody-drug conjugate rovalpituzumab tesirine (Rova-T) may be a new treatment option for patients with small-cell lung cancer (SCLC), which has a very poor prognosis and few treatment options.
Many presentations at ASH 2015 focused on novel therapies currently in development for the treatment of patients with hematologic malignancies.
The multikinase inhibitor midos­taurin is the first targeted therapy to improve overall survival (OS) in patients with acute myeloid leukemia (AML) and the FLT3 mutation.
The oral, investigational, small-­molecule BCL-2 inhibitor venetoclax has shown excellent and durable responses in patients with relapsed or refractory chronic lymphocytic leukemia (CLL). All patients in the trial harbored the 17p deletion (del 17p), which signals poor prognosis.
Immunotherapy with the recently approved anti–PD-1 inhibitor nivolumab prolonged survival in patients with nonsquamous non–small-cell lung cancer (NSCLC) as second-line therapy for disease progression with standard platinum-based therapy.
The oncology pipeline remains robust, especially as the industry embraces the promise of immune checkpoint inhibitors.
Although still a relatively new technique, research is moving fast. Data from 3 separate clinical trials presented at ASCO 2015 highlight the progress being made.
Pembrolizumab achieved “remarkable” results in a phase 1 study of previously treated patients with recurrent, squamous-cell carcinoma of the head and neck, according to presenters at ASCO 2015.
Pembrolizumab achieved “remarkable” results in a phase 1 study of previously treated patients with recurrent, squamous-cell carcinoma of the head and neck, according to presenters at ASCO 2015.
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