Lipids

Chicago, IL—On the 30th anniversary of the landmark Diabetes Control and Complications Trial (DCCT), the results of its 20-year observational Epidemiology of Diabetes Interventions and Complications (EDIC) study showed substantial reductions in the risk of developing severe eye disease, impaired kidney function, heart disease, and stroke with long-term intensive therapy in patients with type 1 diabetes. The results were presented at the 2013 American Diabetes Association annual meeting.
San Francisco, CA—Ranolazine extended release (Ranexa) reduces the frequency of anginal episodes in patients with type 2 diabetes, and its effects are more pronounced in patients with poorer glycemic control, according to new data released at the 2013 American College of Cardiology annual meeting.
Chicago, IL—At the 2013 American Diabetes Association (ADA) annual meeting, John E. Anderson, MD, President of Medicine & Science of the ADA, hosted the President’s Oral Research Sessions I and II, one session focused on basic science and the other on clinical and behavioral science. A subcommittee for the ADA’s Program Committee selected the abstracts of the 2 sessions. Commenting on these sessions, Dr Anderson said, “The Presidential Oral Research Sessions highlight the best and most promising research of all the abstracts submitted to the Scientific Sessions Planning Committee this year.”
Chicago, IL—Diabetes is known to confer approximately a 2-fold increased risk for vascular disease, independent of other cardiovascular (CV) risk factors. The topic was discussed in a session at the 2013 American Diabetes Association (ADA) annual meeting. The presence of diabetes is equivalent in risk to a history of coronary heart disease.
Chicago, IL—Hypoglycemia is a serious concern in elderly patients with type 2 diabetes who often require insulin therapy. Two new analyses presented as late-breaking posters at the 2013 American Diabetes Association annual meeting showed that adding linagliptin to basal insulin in elderly patients reduces the incidence of hypoglycemia in diabetic patients.
San Francisco, CA—New insights into the predictors of outcomes in patients with diabetes were provided by several studies and registries presented at the 2013 American College of Cardiology annual meeting by investigators from around the world.
Chicago, IL—It is estimated that approximately 66% of patients with type 2 diabetes are at risk for declining renal function. A new double-blind, randomized trial of patients with type 2 diabetes and moderate-to-severe renal impairment—estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2—showed that the dipeptidyl peptidase (DPP)-4 inhibitor linagliptin (Tradjenta) significantly reduced hemoglobin (Hb) A1c compared with placebo at 12 weeks (the primary end point); compared with glimepiride in the 40-week extension study, there was less hypoglycemia with linagliptin.
Chicago, IL—The final results of the Look AHEAD study showed that an intensive lifestyle intervention program provides a range of benefits in patients with type 2 diabetes who were overweight and obese. However, it had no impact on the primary outcome of reducing cardiovascular (CV) morbidity and mortality.

Two studies presented at the 73rd Scientific Sessions of the American Diabetes Association, held in Chicago, demonstrate the value of telephone intervention delivered by primary care practices or trained health educators in preventing weight gain in persons at risk for developing diabetes and controlling blood glucose levels in patients with diabetes living in underserved areas.

Symptomatic hypoglycemic episodes, regardless of their severity, in patients with type 2 diabetes is associated with excess cardiovascular risk and all-cause mortality, according to Taiwanese researchers. They published their findings in the April issue of Diabetes Care (2013;36:894-900).

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